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This reexamine examines the pharmacological medicine, pharmacokinetics, drug-fundamental interaction potential, untoward effects, and dosing guidelines for metformin hydrochloride, antiophthalmic factor biguanide federal agent for the handling of typewrite 2 diabetes. Clinical trial information are reviewed, including efficaciousness and tolerability information diet tips for healthy eating, with vitamin A focalize on studies of plural metformin therapy (metformin addition other viva agent or insulin) publicized from 1998 to the present. Pharmacoeconomic considerations ar also discussed.